All-cause mortality, MI, and ischemic stroke Hazard ratio (HR): 0.44, confidence interval (CI) 0.42–0.46 were significantly lower in Gp1 vs. Gp3 in propensity-matched cohorts. All-cause mortality, MI, and ischemic stroke HR: 0.53, CI 0.50–0.55 were significantly lower in Gp1 vs. Gp2 (n = 25,701, median age = 66 years, mean follow-up = 4.6 years). No difference in MI or stroke risk between Gp2 and Gp3. The gene discussed is GTPBP1; the disease is ischemic stroke.