TNFSF10 and hematologic disorder: ABBV-621 (eftozanermin) is an engineered second-generation TRAIL agonist containing IgG1-Fc linked to a single-chain trimer of TRAIL subunits that was tested in phase 1 clinical trials (ClinicalTrials.gov Identifier: NCT03082209) in patients with previously treated solid tumors or hematological malignancies.