TNFSF10 and plasma cell myeloma: Bone and soft tissue sarcomas, in addition to some hematopoietic malignancies, such as multiple myeloma, are susceptible to TRAIL-induced apoptosis and therapy in combination with or without other chemotherapeutic options (Snajdauf et al., 2021; Subbiah et al., 2023; van der Horst et al., 2021; Trivedi and Mishra, 2015).