TNFSF10 and cancer: There have been certain measures implemented to help reduce hepatotoxicity; for example, when using TRAIL in combination with the proteasome inhibitor bortezomib, the use of a lower concentration of bortezomib-induced apoptosis in treatment-resistant cancer cell lines (hepatoma, pancreatic, and colon) but not in primary hepatocytes by working within a specific therapeutic window (Koschny et al., 2007; Yuan et al., 2018; Diaz and Haisma, 2021).