DR4 and DR5 have been found in bone sarcomas (Ewing’s sarcoma, osteosarcoma, and chondrosarcoma) and hematopoietic tumors such as myeloma, with the DR5 receptor being the most frequently expressed (Subbiah et al., 2023; Picarda et al., 2010; Surget et al., 2012; Chen et al., 2013). The gene discussed is TNFRSF10A; the disease is osteosarcoma.