Strong anti-tumor activity has been demonstrated with the combination of anti-DR5 agonist IGM-8444 with the SMAC mimetic, birinapant, in preclinical models using a range of cell lines and PDX models, including sarcoma; for example, 7/9 animals were tumor-free in a model using the HT1080 cell line (Wang et al., 2022), which has also been used to model dedifferentiated chondrosarcoma (Pringle et al., 2022). This evidence concerns the gene TNFRSF10B and chondrosarcoma.