According to the performed multivariate Cox regression model, FAM115C emerged among the genes significantly contributing to the differentiation between HR and LR patients, a result that aligns with previous research identifying it as an oncogene implicated in promoting glioma malignancy and affecting prognosis.40 A recent study has also demonstrated that FAM115C overexpression promotes glioma cell migration and invasion,41 traits that characterize GBM progression. This evidence concerns the gene TCAF2 and central nervous system cancer.