Also, there is an autoimmune-mediated reaction with reported cases of flare of lupus erythematosus, vasculitis, purpura, vitiligo, and alopecia areata, and the most probable reason is that the spike protein of the COVID-19 vaccine is similar to the human protein, which can induce the autoimmune reaction. The gene discussed is CHMP5; the disease is lupus erythematosus.