CTLA4 and metastatic malignant neoplasm in the lymph nodes: These findings were supported by the study conducted by Guo et al., in which CTLA-4 in TILs was found to be associated with aggressive clinicopathologic features, including larger tumour size, lymph node metastasis, and high TNM in intrahepatic cholangiocarcinoma, and stated that overexpression of CTLA-4 in TILs promotes the invasion and metastasis [31].