MAPT and Alzheimer disease: 3xTg: One of the most used AD models is the triple transgenic (3xTg) mouse, which replicates both the tau and Aβ pathologies; Tg-ArcSwe: transgenic mice with the Arctic and Swedish Alzheimer mutations; R1.40, APP/PS1, P301S: these are commonly used mouse models in Alzheimer's Disease.