AD: Alzheimer's disease; TBI: traumatic brain injury; mTOR1: mammalian/mechanistic target of rapamycin 1; PPAR: peroxisome proliferator-activated receptor; NFkB: nuclear factor kappa B; AhR: aryl hydrocarbon receptor; Aβ: amyloid beta; NLRP3: NOD-like receptor protein 3; GSDMD: gasdermin D; ASC Speck: apoptosis-associated speck-like protein containing a CARD (caspase recruitment domain); IL: interleukin. The gene discussed is NLRP3; the disease is early-onset autosomal dominant Alzheimer disease.