The relationship between retinal neurons and TBI-induced AD, neurodegeneration, retinal alterations, tau pathology, SREBP2 and lipid metabolism, ASC speck, pyroptosis, elevated MCP-1 and F4/80 levels, and the potential connection between inflammasome activation and RNFL thinning by the NLRP3 inflammasome are all discussed in this article. The gene discussed is PYCARD; the disease is Alzheimer disease.