Persistent low-level systemic inflammation is also a feature of PCOS, with elevated levels of inflammatory proteins such as Interleukin-6 (IL-6), Tumor necrosis factor alpha (TNF-α), Interleukin-1 (IL-1), and C-reactive protein (CRP), which can impair ovarian function and fertility [5]. The gene discussed is TNF; the disease is polycystic ovary syndrome.