AKT1 and gallbladder cancer: Moreover, TAM-derived CCL18 can stimulate Annexin A2 (AnxA2), which then activates the EMT through the PI3K/Akt/GSK3β/Snail pathway in BC, and similar activation of PI3K/Akt in gallbladder cancer (GBC) promotes cell migration (Zhao et al., 2019; Zhou et al., 2018).