In BC, OSM produced by myeloid cells, including TAMs, activates OSMR on CAFs, inducing secretion of chemokines such as CXCL1 and CXCL16, which attract more TAMs to the tumor site, reinforcing a pro-inflammatory feedback loop that facilitates lung metastasis (Araujo et al., 2022). The gene discussed is CXCL1; the disease is neoplasm.