CCL22 expression by macrophages is modulated through the IL-4/STAT6 signaling pathway, which is pivotal for T cell differentiation into Th2 cells and crucial for CCL22 and VEGF-C expression in tongue squamous cell carcinoma, contributing to lymph node metastasis (Kimura et al., 2021). Here, CCL22 is linked to tongue squamous cell carcinoma.