In renal cell carcinoma, CCL2 secreted by M2 macrophages increases muscleblind like splicing regulator 2 (MBNL2) expression, which in turn stabilizes B-cell lymphoma 2 (Bcl-2) mRNA, leading to the inhibition of Beclin 1-dependent autophagy and endowing RCC cells with invasion properties (He et al., 2023). The gene discussed is MBNL2; the disease is renal cell carcinoma.