Subsequent functional enrichment analysis revealed that the regulatory network of highly insoluble matrisome was associated with various fibrogenesis and carcinogenesis pathways, including ECM-receptor interaction, focal adhesion, PI3K-Akt signaling pathway, platelet activation, TGF-beta signaling pathway, complement and coagulation cascades, small cell lung cancer, proteoglycans in cancer, and pathways in cancer (Figure 3C). The gene discussed is AKT1; the disease is cancer.