F5 and blood coagulation disease: General coagulopathy was determined by several parameters: aPTT, thrombin generation (TAT complexes), acute traumatic coagulopathy [39] (FV, FVIII, and fibrinogen) and/or disseminated intravascular coagulation (DIC; FII, FX, and fibrinogen), and fibrinolysis (fibrinogen, PAP complexes, and D-dimer).