Regulation of MVBs by Rab11 in specific cells might be due to the difference in the origin of MVBs, as MVBs were found to also originate from recycling endosomes positive of Rab11 in some types of cancer cells or Drosophila cells (Fan et al., 2020; Marie et al., 2023; Wells et al., 2023). Here, RAB11A is linked to cancer.