MAPT and dementia: H. pylori may contribute to Aβ deposition and tau phosphorylation in AD patients (Shindler-Itskovitch et al., 2016; McManus and Heneka, 2017), HSV-1 to increased Aβ production (McManus and Heneka, 2017), VZV might activate latent HSV-1, increasing the risk of dementia and exacerbating Aβ-related pathologies (Bubak et al., 2020; Cairns et al., 2022), and HPV is associated with a higher risk of dementia, potentially through oxidative stress and cytokine elevation (Lin et al., 2020).