APOE and early-onset autosomal dominant Alzheimer disease: Modest differences in the associations of the APOE genotype have been reported between men and women for ischemic heart disease (Joshi et al., 2016), Alzheimer’s disease (Corbo and Scacchi, 1999), and lifespan (Finch and Morgan, 2007; Yassine and Finch, 2020), although the reasons underlying these differences are not known.