APOE and Alzheimer disease: The ApoE-Є4 allele (frequency of 0.16 in SiGN) has been associated with numerous adverse health outcomes, including hyperlipidemia (Khalil et al., 2021) and lipid metabolism (Graham et al., 2021), Alzheimer’s disease (Serrano-Pozo et al., 2021) and dementia, and coronary disease (Aragam et al., 2022).