Third, this SNP is biologically compelling as it encodes the ApoE-Є4 allele, which has been associated previously with a shorter lifespan (Mahley, 2016) and several common age-related conditions, including Alzheimer’s disease (Wilson et al., 1996; Bennet et al., 2007; Mahley, 2016; Li et al., 2021) and ischemic heart disease (Garatachea et al., 2014; Caruso et al., 2022). Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.