- Recurrent infections in childhood (details unknown)- Gangrene with sepsis (including ICU treatment) on G-CSF- Severe otitis on G-CSF- Twice urosepsis during pregnancy on G-CSF- Cholesteatoma with Mastoiditis on G-CSF- recurrent febrile infections (e.g., pneumonia) on G-CSF. This evidence concerns the gene CSF2 and gangrene.