Angiogenesis is facilitated by Nrf2 activation in breast cancer, which concurrently inhibits the expression of estrogen-related receptor α and induces upregulation of Rho and Focal adhesion kinase 1, modulator of volume-regulated anion channel current 1, and Rho-associated coiled-coil-containing protein kinase 1 are its downstream proteins. The gene discussed is NFE2L2; the disease is breast cancer.