VISTA, also known as PD-1 homolog (PD-1H), differentiation of embryonic stem cells 1 (Dies1), DD1a, Gi24, SISP1, B7-H5, and C10orf54, is an emerging immune checkpoint protein that promotes cancer progression by suppressing immune responses, thereby making VISTA a promising target for cancer immunotherapy [12,13]. The gene discussed is VSIR; the disease is cancer.