Within the TME, myeloid-derived suppressor cells (MDSCs) contribute to an immunosuppressive environment that aids tumor evasion, which is by increasing the expression of T cell immunoinhibitory receptors, secreting immunosuppressive cytokines like IL-10 and TGF-β, depleting essential amino acids for T-cell activity and proliferation, facilitating the development of tumor-specific Tregs, and encouraging the production of free radical like ROS (Fig. 2) [50]. This evidence concerns the gene TGFB1 and neoplasm.