The study examined the interaction between five hub genes (Cxcl10, Gbp2, Cxcl12, Cxcr3, Ifih1) and four distinct immune cell types (M1 macrophages, NK resting cells, memory CD4 T cells, naive CD8 T cells) in mice brain tissues affected by cognitive impairment. Here, CD8A is linked to Cognitive impairment.