Specifically, CD79A and MS4A1 are highly expressed in B cells; PLVAP and EGFL7 in endothelial cells; MAF and MRC1 in M2-type tumor-associated macrophages; S100A8 and VCAN in monocytes; IFIT1 and CXCL10 in M1-type tumor-associated macrophages; COL3A1 and COL1A1 in cancer-associated fibroblasts; MZB1 and IGHG1 in plasma cells; CTSK and ACP5 in osteoclasts; RUNX2 and ALPL in osteoblasts; CD3E and CD2 in NK/T cells (Figure 3C). Here, VCAN is linked to cancer.