For example, METTL3 promotes the formation of circ-IGF2BP3 in a YTHDC1-dependent manner, protecting PD-L1 from proteasome-mediated degradation, thereby reducing CD8+ T cell infiltration and promoting immune evasion of non-small cell lung cancer (NSCLC) cells. This evidence concerns the gene YTHDC1 and non-small cell lung carcinoma.