IFNG and hepatocellular carcinoma: Furthermore, KIR2DS2high NK cells demonstrated enhanced degranulation and IFNγ expression against HCC cells alone and in combination with avelumab compared to KIR2DL3/L2high and KIR2DL3/L2/S2- NK cells (p<0.01 or p<0.05, respectively) (Figures 1D-F).