KIR2DL3 and hepatocellular carcinoma: Using a previously published flow cytometry panel to separate NK cells based on KIR2DL3/L2/S2 expression (Supplementary Figure 2) (37), KIR2DS2high NK cells demonstrated significantly higher degranulation against HCC cells compared with KIR2DL3/L2high and KIR2DL3/L2/S2- NK cells alone and in combination with all concentrations of cetuximab tested (p<0.01 or p<0.05) (Figures 1A, B).