CDKN2A and head and neck cancer: In contrast to head and neck cancer, it is believed that HPV-positive cervical cancer is less chemoresistant as DNA damage repair is altered due to genetic HPV-induced changes in pathways involving, among others, TP53, cyclin dependent kinase inhibitor 2A (CDKN2A/p16), and lysine acetyltransferase 5 (KAT5/TIP60) (45).