HBEGF and cancer: We could confirm these studies by showing that most of the pathological effects of these proteases in relation to cancer can be explained by enhanced growth factor release of amphiregulin (AREG), heparin binding-EGF like growth factor (HB-EGF), or epithelial growth factor (EGF) by binding to their respective receptors like epithelial growth factor receptor (EGFR), Erb-B2 receptor tyrosine kinase 2 (ERBB2/HER2), HER3, and other receptor tyrosine kinases (6).