Repression of PGAM5 inhibits Drp1-dependent mitochondrial fission [12], blocks the mitochondrion-related apoptosis pathway [15], and interrupts mitochondrial permeability transition pore (mPTP)-mediated necroptosis [17], highlighting that PGAM5 functions as a pivotal effector for the induction of mitochondrial dysfunction in various cardiovascular disorders. The gene discussed is PGAM5; the disease is cardiovascular disorder.