PHB1 and Hyperglycemia: In turn, hyperglycemia-mediated PHB2 dephosphorylation at S91 was not affected by PHB2 mutants lacking the N-terminal domain (PHB2ΔN), the C-terminal domain (PHB2ΔC), or the coiled-coil domain (PHB2ΔCC) but was instead prevented by mutants lacking the PHB domain (PHB2ΔPHB) (Fig. S4A and B).