EGFR and Alzheimer disease: Research into the molecular mechanisms by which neuregulin regulates myelination through its interactions with ErbB receptors on oligodendrocytes showed that perturbations in neuregulin-ErbB signaling lead to the myelin defects observed in AD, including the thinning of myelin sheaths and reduced myelin integrity, which are hallmarks of the disease (Xie and Zheng, 2013).