The ablation of Dicer selectively in SCs, including SCs expressing PLP, results in a significant decrease in Dicer-related miRNAs, and impairments of development and maintenance of myelination and axonal integrity, leading to peripheral neuropathy(Pereira et al., 2010; Viader et al., 2011; Gokbuget et al., 2018; Li et al., 2018). Here, DICER1 is linked to peripheral neuropathy.