These downregulated miRNAs likely contribute to the peripheral neuropathy observed in the PLP-cKO mice, because these miRNAs target myelin inhibitory proteins of c-Jun, Sox2 and Notch, and axonal inhibitory proteins of PTEN (Yun et al., 2010; Viader et al., 2011; Li and Sun, 2013; Sathyan et al., 2015). This evidence concerns the gene SOX2 and peripheral neuropathy.