Disrupted copper homeostasis has been shown to increase oxidative stress, neuroinflammation and aggregation of neurotoxic proteins such as α-synuclein, beta amyloid (Aβ) and tau implicated in neurodegenerative diseases (Brewer, 2008; Kitazawa et al., 2009; Lim et al., 2020; Wei et al., 2024). This evidence concerns the gene MAPT and neurodegenerative disease.