MAPT and neurodegenerative disease: Disrupted homeostasis of copper has been shown to increase oxidative stress, promote aggregation of neurotoxic proteins implicated in neurodegenerative diseases including α-synuclein, Aβ, and tau and, to increase neuroinflammation (Brewer, 2008; Kitazawa et al., 2009; Dell'Acqua et al., 2015; Lim et al., 2020; Patel and Aschner, 2021).