Furthermore, the interplay between ERα‐46 and insulin receptor in patient‐derived immortalized cells (BCAHC‐1) induces the expression of interleukin 11, a cytokine that regulates the expression of ECM molecules, such as ICAM‐1 and α5 integrin, mediating the invasion and migration of breast cancer‐associated fibroblasts (CAFs) and the consequent metastasis of breast cancer to the lungs (Fig. 4) [8]. This evidence concerns the gene ICAM1 and breast carcinoma.