To prepare the multiomics dataset for the analysis, we select three omics inputs: APOE genotypes, APOE gene expression levels and biomarker “A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{upgreek}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}$\beta$\end{document}-42” [29], which are recognized to affect AD pathology. The gene discussed is APOE; the disease is Alzheimer disease.