Next, the top 15 targets respectively ranked by Dgree, Closeness, and Betweenness were intersected, and we finally obtained nine targets, including TNF, MAPK8, FOS, RELA, PPARG, CASP3, PTGS2, EGFR, and GAPDH (Fig. 2D, E, Table 2), which were considered as the hub targets of mSMG against IR in T2DM. This evidence concerns the gene CASP3 and type 2 diabetes mellitus.