Besides, mSMG and mSMG-MS significantly enhanced glucose consumption, GS activity, and glycogen synthesis, relieved the phosphorylation of JNK1 and IRS-2 (Ser388) proteins, and elevated the phosphorylation of Akt (Ser473) and GSK-3β (Ser9) as well as the expression of GLUT2 protein in KK-Ay T2DM mice and IR-HepG2 cells. The gene discussed is IRS2; the disease is type 2 diabetes mellitus.