Comparisons of tau-PET uptake in all four neocortical composite regions and the LEADS signature show higher uptake in AD groups compared to controls and aEOAD showed a significantly higher tau-PET uptake in these neocortical composite regions compared to aLOAD (see sTable S6, sFig. S13 and sFig.S15). This evidence concerns the gene MAPT and Alzheimer disease.