SLC5A2 and hydrops fetalis: The diuretic effect of MRA is relatively weak, and the beneficial effect of MRAs on HF has been attributed to non-diuretic effects [13]. On the other hand, SGLT2 inhibitors can increase urine output in HF patients [14]. Owing to these differences, we implemented PS matching to adjust for confounding factors, and differences in fluid levels were observed (Fig. 3B), suggesting that ARNI may potentially enhance the diuretic effect of hANP more effectively than ARB.