CCNG2 and Bloom syndrome: Thereby we found a potential binding side for miR-1246 in the 3’UTR of cyclin G2 (CCNG2) (Fig. 6A)When we treated BLM cells with EVs derived from BLM-HI cells the protein level of CCNG2 decreased, while LNA-mediated block of miR-1246 resulted in an increase of CCNG2 protein (Fig. 6B).