The study of Li et al. on the radiomics of glioma established the intratulotumor multi-region model and peritulotumor model, and the results showed that the radiomics model containing multiple regions was better than the single-region model for predicting the mutation status of IDH-1 [32], which opened up ideas for subsequent ROI delineation. Here, IDH1 is linked to central nervous system cancer.