ADIPOQ and ovarian cancer: Adipocyte activity in these tissues was confirmed by adiponectin ELISA (Figure S1A) and ovarian cancer cell lines (SKOV-3, OVCAR-3, UACC1598, UWB1.281, CAOV3) were treated with 50% OT-CM in two-dimensional (2D) monolayer (Fig. 1A) and three-dimensional (3D) spheroid culture (Fig. 1B).