SOX10 and neoplasm: Here, we showed that the suppression of SOX10 is sufficient to mediate the transition of OLC-like (SOX10-high/SOX9-low) to NSC-like (SOX10-low/SOX9-high) tumor phenotypes, in line with the roles of these transcription factors in determining cell-lineage identities during normal development (Glasgow et al, 2014; Scott et al, 2010; Stolt et al, 2002).