NES and neoplasm: In line with these findings, SOX10 expression was significantly anti-correlated with SOX9, EGFR, NES, and PAX6 (Fig. 1B), suggesting that SOX10-high and SOX10-low tumor cells exhibit disparate lineage propensity, with SOX10-low tumor cells occupying an AC-like or NSC-like cellular state characterized by high SOX9 and EGFR expression (Cancer Genome Atlas Research, 2008; Neftel et al, 2019; Verhaak et al, 2010).