SOX10 expression was proposed to be suppressed by therapy-related factors, i.e., radiation treatment in a glioblastoma mouse model (Lau et al, 2015), TGF-β-mediated stress signaling activated by irradiation, hypoxia, or TMZ in human glioma cells (Tabatabai et al, 2006), and BRAF inhibition in melanoma patients (Capparelli et al, 2022; Sun et al, 2014). Here, BRAF is linked to central nervous system cancer.