In addition, analysis of a curated brain tumor stem cell transcriptome dataset (Marques et al, 2021) (n = 144, 116 independent lines) indicated that SOX10-low brain tumor stem cells are enriched for qNSC (Kalamakis et al, 2019) and quiescent stem cell tumor cell (Xie et al, 2022) signature (Fig. EV3F), validating the association of SOX10-low and NSC-like state. Here, SOX10 is linked to brain neoplasm.