LEP and Insulin resistance: In all subjects, SBP had significant positive correlations with BMI, % fat, fat mass, serum insulin levels, the homeostatic model assessment for insulin resistance (HOMA-IR), and serum leptin levels at baseline and week 8; and with BW and hip circumference at week 8; but had significant negative correlations with high-density lipoprotein cholesterol (HDL-C) and the quantitative insulin sensitivity check index (QUICKI) at baseline and week 8 (P < 0.05 all) (Table 2).