ESR1 and neoplasm: The change in MRI tumor load model evaluated in the ER+/HER2− patient group yielded an estimated CV AUC of 0.67(95% CI 0.51–0.84), the %TILs-only model an estimated CV AUC of 0.68 (95% CI 0.50–0.82), while the combined model had an estimated CV AUC of 0.72 (95% CI 0.60–0.88).