The following variables were positive predictors of STC and were included in the final model: age >  60 years, male sex, diabetes mellitus, acute cholecystitis (AC), increased severity of AC (CRP > 90 mg/L), ≥ 3 biliary admissions, pre-operative ERCP with/without stent, pre-operative cholecystostomy and emergency LC (AUC = 0.84). Here, CRP is linked to Cholecystitis, Acute.