We fine-mapped each of the risk loci, including independent signals, incorporating functional annotation using PolyFun26 and susieR27 in conjunction with ChIP–seq data on H3K4me1, H3K4me3, H3K27ac, H3K27me3, H3K36me3 and CCCTC-binding factor (CTCF) marks, as well as assay for transposase-accessible chromatin with sequencing (ATAC-seq) data generated from six CRC cell lines (C32, CL11, HT29, SW403, SW480 and SW948) (Supplementary Table 1). The gene discussed is CTCF; the disease is colorectal carcinoma.