7D supplementation (8 mg/kg body weight) to DENV2-infected mice improved synthesis of IFN-α/β and IFN-λ via CXCL4:CXCR3:p38:IRF3 pathway and rescued disease symptoms like thrombocytopenia and leukopenia, decreased vascular-leakage and increased survival. This evidence concerns the gene IFNA1 and Decreased total leukocyte count.