The inhibition of mTORC1 at low pH has been described in fibroblasts and tumor cells (Balgi et al, 2011; Faes et al, 2016; Walton et al, 2018) and it has been proposed that acidification within the cytoplasm causes lysosome dispersion thereby preventing mTORC1 co-localization with its activator Rheb (Walton et al, 2018). This evidence concerns the gene RHEB and neoplasm.