A GCB PDX model, VFN-D7 DHL with low PTEN protein (Fig. 5A) expression harbours both a BCL2 and MYC translocation, hallmarks of double hit lymphoma and the VFN-D1 KTC PDX model has wildtype PTEN protein levels (Fig. 5A), a BCL2 amplification and MYC copy number gain. This evidence concerns the gene MYC and lymphoma.