PIK3CA and diffuse large B-cell lymphoma: Relapsed/refractory GCB-DLBCL has a high incidence of PTEN protein loss [6], and GCB DLBCL cell lines and tumour models are sensitivity to AKT inhibition [7, 13], underscoring the importance of the PI3K-AKT signalling axis in GCB-DLBCL.