A higher degree of genomic instability represented by more frequent CNVs was observed in MCL Elderly (36/41, 88%) compared to MCL Younger patients (60/76, 79%), represented by more frequent deletions affecting RB1 (34% vs. 22%), ATM (29% vs. 14%), CDKN2A/B (27% vs. 16%), and TP53 (22% vs. 14%) and more frequent amplifications affecting CCND1 (17% vs. 9%) and MAP2K1 (20% vs. 9%) (Fig. S3). The gene discussed is RB1; the disease is mantle cell lymphoma.