Strikingly, but consistent with the amelioration of the defects in gephyrin aggregation and sIPSC frequency and amplitude, female, Nlgn2/MDGA1 dKO mice showed an amelioration of the profound Nlgn2 KO anxiety phenotype as indicated by a normalization of the time spent in the center of the open field chamber (Fig. 6d, light blue bars vs. grey bars, and Supplementary Table 7). Here, NLGN2 is linked to Anxiety.