GPHN and Anxiety: Strikingly, but consistent with the amelioration of the defects in gephyrin aggregation and sIPSC frequency and amplitude, female, Nlgn2/MDGA1 dKO mice showed an amelioration of the profound Nlgn2 KO anxiety phenotype as indicated by a normalization of the time spent in the center of the open field chamber (Fig. 6d, light blue bars vs. grey bars, and Supplementary Table 7).