No amelioration of the Nlgn2 KO anxiety phenotype was observed in male or female Nlgn2 KO/MDGA2 Het mice (Supplementary Fig. 5f-h and Supplementary Table 7), consistent with the lack of an effect of MDGA2 Het on gephyrin aggregation and GABAergic synaptic transmission (Supplementary Fig. 5a–c and Supplementary Table 7). This evidence concerns the gene MDGA2 and Anxiety.