Furthermore, T24L and 253J-BV cells were treated with specific inhibitor of SPHK1 (i.e., FTY720) and a dose-dependent inhibitory effect of FTY720 on both cell migration and invasion of T24L and 253J-BV cells (Fig. 2E); these concentrations were not toxic to these cells (Fig. S2). The gene discussed is SPHK1; the disease is bacterial vaginosis.