Ubiquitin-specific processing proteases (USP or UBP in yeast), the ubiquitin C-terminal hydrolases (UCH), ovarian tumour-related proteases (OTU), and the Josephin/Machado–Joseph disease proteases (MJD) constitute the cysteine protease DUB family while JAB1/MPN/Mov34 metalloenzyme (JAMM) comprise the zinc-dependent metalloprotease DUB family [11]. This evidence concerns the gene ZUP1 and neoplasm.