However, the regulatory mechanism of DNMT3A expression in CRC has not been well-defined and needs further investigation. In the present study, we confirmed the function of SYNCRIP in regulating colorectal cancer cells growth in vitro and in vivo and proved that the expression of DNMT3A was regulated by SYNCRIP, which suggested SYNCRIP as a potential therapeutic target for colorectal cancer. This evidence concerns the gene DNMT3A and colorectal cancer.