HIF1α activity downregulates the expression of carnitine palmitoyltransferase 1A (CPT1A) and medium- and long-chain acyl-CoA dehydrogenases, key enzymes for the import of mitochondrial fatty acids and for the β-oxidation of lipids, thus limiting fatty acid catabolism in cancer cells (Du et al., 2017; Huang et al., 2014; Miess et al., 2018). The gene discussed is HIF1A; the disease is cancer.