MFN2 and Charcot-Marie-Tooth disease type 2A1: MFN2 T105M, either expressed using adenoviral vectors in mouse embryonic fibroblasts or in the context of a heterozygous mutation in dermal fibroblasts from a human CMT2A patient, inhibits normal mitochondrial fusion, manifested as mitochondrial fragmentation, depolarization, and clumping (Detmer and Chan, 2007; Dang et al., 2022).