We observed high expression of all 5 markers in SARS-CoV-2-specific CD8+ and CD4+ T cells and moderate expression in total CD8+ and CD4+ T cells during acute SARS-CoV-2 infection, in both long COVID and non-LC groups (Fig. 3C and SI Appendix, Fig. S4B). Here, CD4 is linked to laryngotracheoesophageal cleft.