As we have previously shown, non-Tfh cell populations are different between adjuvanted rGP immunization and LCMV infection [63], investigating the CD4+ TRM subsets resultant from these priming strategies and their distinct roles in their recall during an influenza challenge poses an interesting question, as IFNγ-secreting CD4+ T cells have been shown to be protective against influenza infection in secondary recalled responses [127,128]. The gene discussed is IFNG; the disease is influenza.