GDF15 and Pleural effusion: To further support the value of GDF-15 level as a biomarker of EHE aggressiveness, we reported on a higher-risk patient (Fig. 5C), who developed disease progression at the right lung together with pleural effusion between February and May 2022, which was associated to a marked increase of GDF-15 level from 6,792 to 11,475 pg/mL.